A Genetic Switch: Phage Lambda RevisitedCold Spring Harbor Laboratory Press, 2004 - 154 עמודים The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works. |
תוכן
CHAPTER | 4 |
THE MASTER ELEMENTS OF CONTROL | 11 |
CHAPTER | 31 |
זכויות יוצרים | |
11 קטעים אחרים שאינם מוצגים
מהדורות אחרות - הצג הכל
A Genetic Switch: Phage Lambda Revisited <span dir=ltr>Mark Ptashne</span> תצוגה מקדימה מוגבלת - 2004 |
מונחים וביטויים נפוצים
action activation addition adjacent affinity amino acids amino domain bacterial bacteriophage bacterium base pairs bearing begin bound called carboxyl domain cells Chapter chromosome cleaves coli complex contacts cooperativity curve described determine early effect efficiently example experiment fact function gene genetic groups grow helix helps host identical immune increase indicated induction infection integration interactions involved lac repressor Lambda lysogen lytic growth major groove mechanism monomers mRNA mutant noted octamer operator sites phage phosphate picture position presence promoter protein Ptashne reaction RecA recognition recognizes References region regulation regulatory protein repres repression repressor and Cro repressor binds repressor concentration repressor dimer residues RNA polymerase separated sequence shown in Figure shows single specific stimulates strand structure studies surface switch synthesis tetramers tion transcribed transcription turns wild-type