Reviews of Physiology, Biochemistry and Pharmacology, כרך 144Springer Science & Business Media, 14 בפבר׳ 2002 - 227 עמודים In this volume of Reviews there are three outstanding articles, one on phspholipase D, an enzyme that is widely distributed in bacteria, protozoa, fungi, plants and animals. Phospholipase D carries out a transphosphatidylation reaction, which is unique to this enzyme. This review is focussed on mammalian PLDs. The second review deals with endotoxin tolerance, the term which describes the phenomenon that immune responses and metabolic changes are mitigated after repeated LPS administration. The third article summarizes the current knowledge relevant to understanding the molecular basis of GPCR function and focusses on the underlying mechanisms of GPCR malfunctions responsible for diferent human diseases. |
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Acad Sci USA activation of PLD ADP-ribosylation factor adrenergic receptor agonists amino acid associated AVPR2 bacterial binding Biochem Biol Chem Biophys Ca2+ Clin constitutively active cytokine cytosolic deletion desensitization diacylglycerol dimer domain effects Endocrinol endotoxin endotoxin tolerance enzyme expression Exton JH extracellular fibroblasts formation G protein-coupled receptor G proteins Genet genomic Golgi GPCR GTPYS hormone receptor human Immunol inactivating induced inhibition inhibitor interaction interleukin-1 involved isozymes ligand lipid lipopolysaccharide loop macrophages mammalian mechanism mediated mice molecular monocytes motif mouse mRNA muscarinic mutations Natl Acad Sci neutrophils pathway peptide phenotype phosphatidic acid phospholipase phospholipase D activity phosphorylation PIP2 plasma membrane PLD activity PLD1 PLD2 pretreatment Proc Natl Acad protein kinase protein-coupled receptor recep receptor function receptor gene regulation residues response RhoA rhodopsin role Schöneberg sequence splice stimulation structure studies tion translocation transmembrane tumor necrosis factor vitro vivo