Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986

Dimitrios Theodoropoulos

Walter de Gruyter GmbH & Co KG, 8 באוק׳ 2019 - 703 עמודים

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In memoriam Karel Jost	1

AN INTRODUCTORY NOTE	5

THE MEMBRANE COMPARTMENT CONCEPT FIRST JOSEF RUDINGER MEMORIAL LECTURE	7

MAIN LECTURES	25

KNOWLEDGEBASED DESIGN OF NOVEL PEPTIDES	35

STRUCTUREACTIVITY RELATIONSHIPS	43

PROTECTION	61

SELECTIVE PROTECTION OF CYSTEINE WITH FERROCENE DERIVATIVES	65

A 2D PROTON CONFORMATIONAL ANALYSIS OF TWO SYNTHETIC AMATOXINS ANALOGS	357

SURFACTANTINDUCED ORDERED STRUCTURES OF GASTRIN RELATED PEPTIDES	361

CycloPheDTrpLysThrompAMPA	365

INVESTIGATION OF CARBAZOLCARBONYLSUBSTITUTED POLYɑLYSINE polyNsup6sup9Hcarbazol9ylcarbonyllysine	369

BIOPHYSICAL PROPERTIES OF SYNTHETIC PRESEQUENCES SUGGEST CONFORMATIONS IMPORTANT FOR PROTEIN LOCALIZATION	373

NEUROPEPTIDES	377

SYNTHESIS AND BIOLOGY OF CYCLIC ENKEPHALIN PSEUDOPEPTIDES	381

DESIGN AND SYNTHESIS OF RECEPTOR SELECTIVE PEPTIDE NEUROTRANSMITTERS	385

ADVANTAGES AND DISADVANTAGES IN THE USE OF FORMIC ACID IN PEPTIDE SYNTHESIS	69

DIBENZYL DICARBONATE Zsub2subO A NEW CARBOBENZOXYLATING REAGENT	73

APPLICATION OF FLUORENYLMETHYL ESTERS IN THE SYNTHESIS OF VIRAL PROTEIN FRAGMENTS	75

ELECTROCHEMICAL CLEAVAGE OF PROTECTING GROUPS	79

A METHODOLOGY OF SYNTHESIS	81

AMMONOLYSIS MEDIATED SIDE REACTIONS OF ßTBUTYLASPARTYL PEPTIDES	83

THE PHENOTHIAZINYL10CARBONYL PC RESIDUE A NOVEL AMINOPROTECTING GROUP FOR PEPTIDE SYNTHESIS	87

THEIR USE IN THE SYNTHESIS OF PEPTIDES	91

TFMSATFA CLEAVAGE AND DEPROTECTION IN SPPS	97

INCLUDING RACEMISATION	103

USE OF FMOC AMINO ACID CHLORIDES IN THE SYNTHESIS OF TACHYKININ SEQUENCES AND INVESTIGATION OF THEIR HISTAMI...	107

IMPROVED PREPARATION OF CRYSTALLINE N9XANTHYL AMINO ACID NCARBOXYANHYDRIDES FOR PEPTIDE SYNTHESIS	111

THE OPTIMIZATION OF REACTION CONDITIONS FOR PEPTIDE SYNTHESIS BY MEANS OF NNBIS2OXO3OXAZOLIDINYLPHOSPHORO...	115

APPLICATION OF MIXED PHOSPHINIC ANHYDRIDES IN FRAGMENT CONDENSATION OF PEPTIDES	119

A NEW PRINCIPLE FOR FRAGMENT CONDENSATION OF PEPTIDES	123

SYMMETRICAL ANHYDRIDE REARRANGEMENT LEADS TO THREE DIFFERENT DIPEPTIDE PRODUCTS	127

POLYMER SUPPORTED PEPTIDE SYNTHESIS	131

DESIGN OF REAGENTS FOR SOLID PHASE SYNTHESIS	135

SYNTHESIS OF THE CARBOHYDRATEFREE VESPULAKININ 1 BY THE CONTINUOUS FLOW SOLID PHASE PROCEDURE AND BY A CO...	139

FACILE SOLIDPHASE PREPARATION OF PEPTIDES CONTAINING THE CH2NH PEPTIDE BOND ISOSTERE AND APPLICATION TO THE S...	143

SYNTHESIS OF A KARYOPHILIC PEPTIDE COVALENTLY BOUND TO PHOSPHATIDYLETHANOLAMINE	147

GEL PHASE 13C NMR INVESTIGATION OF HYPERHIGH LOAD SOLID GEL PHASE SYNTHESIS OF AN LHRH 15 ASSEMBLY	151

LIQUID PHASE PEPTIDE SYNTHESIS EMPLOYING A PHENOLIC MODIFICATION OF THE POLYETHYLENE GLYCOL SUPPORT	155

A COMPARISON OF DIFFERENT METHODS FOR THE PREPARATION OF BENZHYDRYLAMINE RESINS	159

THIOETHER LINKAGES BETWEEN PEPTIDE SYNTHETIC INTERMEDIATES AND SOLID SUPPORTS	163

SOLID PHASE COUPLING OF PROTECTED PEPTIDE SEGMENTS INFLUENCE OF THE POLYMER SUPPORT	167

ATTEMPTS AT THE SYNTHESIS OF FOLLICLE STIMULATING HORMONE RELEASING PROTEIN FRP	171

PEPTIDE CYCLIZATIONS ON POLYMERIC SUPPORTS SITE ISOLATION VERSUS SITE SITE INTERACTION	175

SOLID PHASE PEPTIDE SYNTHESIS WITH FMOCAMINO ACIDS AN ALTERNATIVE PROTOCOL	179

ENZYMATIC SYNTHESIS SEMISYNTHESIS RECOMBINANT SYNTHESIS	183

BIOSYNTHESIS OF HUMAN INSULIN IN YEAST VIA SINGLECHAIN PRECURSORS	189

STUDIES ON SYSTEM PROPERTIES INFLUENCING THE PARTITION CONSTANT IN KINETICALLY CONTROLLED ENZYMATIC PEPTID...	195

ENZYMATIC SYNTHESIS OF ASPARTAME A STUDENT EXPERIMENT	199

ENZYMATIC SYNTHESIS OP FRAGMENTS OF THE GONADOTROP RELEASING HORMONE MOLECULE WITH LHRHFSHRH ACTIVITY	203

NUCLEOPHILE BINDING IN CHYMOTRVPSIN PEPTIDE SYNTHESIS	207

SYNTHESIS AND PROPERTIES OF Hsesup65sup Ala sup81sup Hsesup65 sup Leusup81sup and Hsesup65 supValsup81sup CYTOCHROME	211

PREPARATION OF ARG B31 INSULIN	215

ENZYMEASSISTED SEMISYNTHESIS OF POLYPEPTIDE ACTIVE ESTERS FOR SUBSEQUENT SPONTANEOUS COUPLING	219

INCLUDING LABELLING LARGE SCALE SYNTHESIS ANALYSIS AND PURIFICATION	223

DDZ A HIGHLY EFFICIENT PROTECTING GROUP IN LARGE SCALE SYNTHESES OF THYMOSINalpha 1 RELATED PEPTIDES	227

CHEMICAL SYNTHESIS OF TRICHOTOXIN A MEMBRANE ACTIVE POLYPEPTIDE MYCOTOXIN	231

CHEMICAL PHOSPHORYLATION OF SERINE PEPTIDES RELATED TO SUBSTRATES OF CYCLIC AMPDEPENDENT PROTEIN KINASE	235

COMPARISON OF FOUR APPROACHES TO THE SYNTHESIS OF RAT ATRIAL NATRIURETIC POLYPEPTIDE ANP	239

SEQUENCE ANALYSIS OF THE ANTIBIOTIC EPIDERMIN A HETERODET TETRACYCLIC 21PEPTIDE AMIDE	243

ISOLATION AND STRUCTURE IDENTIFICATION OF A NEW MAST CELL DEGRANULATING PENTADECAPEPTIDE FROM PARAIE5PUL...	247

PEPTIDES CONTAINING ɑɑDISUBSTITUTED AMINO ACIDS EXPERIMENTS RELATED TO ɑHYDROXYMETHYLSERINE	251

PROTAMINES VI TOTAL SYNTHESIS OF PERORNITHINETHYNNINE Z1 AND AMIDINATION STUDIES	255

MULTIPLE POSITIONS 3HLABELLING OF GROWTH HORMONE RELEASING FACTORS	259

THE SYNTHESIS OF CYSTEINECONTAINING FRAGMENTS RESIDUES 612 AND 1320 OF CLOSTRIDIUM BUTXRICUM APOFERREDOXIN	263

FAILURE TO LABEL PROLINE WITH TRITIUM BUT SUCCESSFUL INTRODUCTION OF sup35supSCYSTEINE	267

CONTRIBUTION TO LANTHIONINE AND CYCLOLANTHIONINE CHEMISTRY	271

LARGESCALE SYNTHESIS OP GRF129 AND 144 AMIDES	275

PRESSSTUD PROTEIN CONJUGATES	279

B PHYSICAL STUDIES ON PEPTIDES	283

SYNTHETIC HELICAL PEPTIDES	287

CONFORMATIONACTIVITY RELATIONSHIPS IN THE SERIES OF MURAMYLPEPTIDES	291

NMR STUDY OF THYMULIN A THYMIC NONAPEPTIDE HORMONE INFLUENCE OF ZnII COMPLEXATION ON THE CONFORMATIONAL...	295

OXYGEN17 NMR STUDIES OF ENKEPHALINS IN AQUEOUS SOLUTION	299

COPARISON WITH SUBSTANCE P AND PHYSALAEMIN	303

THE CONSTRUCTION OF NEW PROTEINS DESIGN SYNTHESIS AND CONFORMATIONAL PROPERTIES OF POLYPEPTIDES WITH ßɑßT...	307

CONFORMATIONAL STUDIES ON THREE CYCLIC HEXAPEPTIDES RELATED TO THE SEQUENCE 711 OF SOMATOSTATIN	311

Accsup5sup AND Accsup6supCONTAINING PEPTIDES	315

SYNTHESIS AND XRAY ANALYSIS OF OLIGOPEPTIDES CONTAINING ɑAMINOISOBUTYRIC ACID AIB	319

CONFORMATIONAL EFFECT OF PEPTIDE BACKBONE MODIFICATIONS	323

COMMON STRUCTURAL FEATURES FOR CYTOPROTECTION ACTIVITY OF CYCLIC RETRO ANALOGUES OF SOMATOSTATIN	327

SOLUTION CONFORMATION OF CONOTOXIN GI	331

CHEMICAL SHIFTS FOR THE AROMATIC PROTONS OF SELECTED ANALOGUES IN DMSOdsub6sub AT 40 0MZ	335

CONFORMATIONAL STUDIES OF CARBAANALOGS OF OXYTOCIN	341

CONFORMATIONAL ANALYSIS OF CHOLECYSTOKININ CCKsub2733sub AND CCKsub2633sub BY sup1supH NMR SPECTROSCOPY FLUO...	345

AN INTRAMOLECULAR CHARGETRANSFER COMPLEXES APPROACH	349

SPECTROSCOPIC STUDIES OF SYNTHETIC PEPTIDE CHEMOATTRACTANTS	353

SYNTHESIS AND STRUCTUREACTIVITY RELATIONSHIPS OF SIDECHAIN TO SIDECHAIN CYCLIZED OPIOID PEPTIDE ANALOGS	389

SYNTHESIS AND BIOLOGICAL ACTIVITY OF ENKEPHALIN RELATED GLYCOPEPTIDES	393

DESIGN SYNTHESIS AND BIOLOGICAL ACTIVITY OF SELECTIVE AGONISTS FOR TACHYKININ RECEPTOR SUBTYPES	397

DISILOXANEBRIDGED BIOLOGICALLY ACTIVE ANALOGUES OF THE ENKEPHALINS	401

CHARACTERIZATION OF A THIRD TACHYKININ RECEPTOR SPN IN THE MAMMALIAN NERVOUS SYSTEM	405

SYNTHESIS OF PEPTIDES CONTAINING REPEATING SEQUENCES OF ENKEPHALIN	409

SYNTHESIS AND BIOLOGICAL PROPERTIES OF PERIPLANETIN CC2 COCKROACH NEUROPEPTIDE PROM CORPORA CARDIACA OP PE...	413

A NOVEL μSPECIFIC REACTIVE LIGAND OF THE OPIATE RECEPTOR	417

STUDIES ON CARBOXYL TERMINALLY EXTENDED DERMORPHINS	421

SYNTHESIS OP ANALOGS OP ENKEPHALIN DERIVATIVES OP 2DALA5DESMET ENKEPHALIN HYDRAZIDE AT THE FIRST AND FOUR...	425

SYNTHESIS AND PRELIMINARY BIOLOGICAL RESULTS OF DIMERIC DERMORPHIN LIKE PEPTIDES	431

ENKEPHALIN ANALOGUES CONTAINING POLAR AMINO ACID RESIDUES	435

CONFORMATIONS OF TACHYKININ PEPTIDES IN MEMBRANE ENVIRONMENTS	439

CONFORMATION ACTIVITY RELATIONSHIP OF A SERIES OF PEPTIDES RELATED TO DERMORPHIN A 500 MHz NMR STUDY	443

GASTROINTESTINAL PEPTIDES	447

CYCLIC HEXAPEPTIDE CCK ANTAGONISTS	451

SYNTHESIS OF PSEUDOPEPTIDE AND PEPTIDE ANALOGUES OF THE CTERMINAL HEPTAPEPTIDE OF CHOLECYSTOKININ AND PREL...	455

ANTERIOR AND POSTERIOR PITUITARY PEPTIDES	459

VASOPRESSIN ANALOGS WITH STRONG AGONISTIC ANTAGONISTIC PROPERTIES	465

PHOTOREACTIVE AGONISTS AND ANTAGONISTS OF NEUROHYPOPHYSIAL HORMONES FOR RECEPTOR STUDIES	469

AC THPHOTOAFFINITY LABELS SYNTHESIS AND APPLICATION OF ANALOGUES WITH AGONISTIC AND PARTIAL AGONISTIC PROP...	473

THE INFLUENCE OF PEPTIDERECEPTOR DISSOCIATION RATE CONSTANTS ON RESPONSES TO AND APPARENT POTENCY OF PEPTID...	477

C BIOLOGICALLY ACTIVE PEPTIDES	479

SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL GROWTH HORMONE RELEASING FACTOR ANALOGS	481

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF THREE ARGININE VASOPRESSIN ANALOGS WITH 4HYDR0XYPR0LINE IN POSITION 7	485

STUDIES WITH PEPTIDES RELATED TO THE SEQUENCE 49 OF ACTH	489

SYNTHESES OF NEW VASOPRESSIN ANALOGUES	493

OXYTOCIN ANALOGS CONTAINING TWO DISULFIDE BONDS	497

SYNTHESIS OF ALASUBSTITUTED ANALOGS OF ACTHαMSH410 AND THEIR EFFECTS ON STEROIDOGENESIS AND PIGMENT DISPER...	501

SYNTHESIS AND BIOLOGICAL ACTION OF ACTHMSH FRAGMENTS CONTAINING MELPHALAN	505

NOVEL GnRH AGONISTS CONTAINING LβASPARTIC ACID DERIVATIVES IN POSITION 6	509

CHARACTERIZATION OF NOVEL SPECIES SPECIFIC GnRH ANALOGS WHICH CAN BE USED FOR THE INDUCED ARTIFICIAL PROPAGA...	513

PANCREATIC PEPTIDES	517

NEW PHOTOREACTIVE DERIVATIVES OF INSULIN FOR AFFINITYLABELLING OF THE INSULIN RECEPTOR	521

NEW APPROACHES TO PROINSULIN RELATED CONVERSION INTERMEDIATES	525

DEVELOPMENT OF SPECIFIC ANTISERA AND ANALYSIS OF PROGLUCAGON PROCESSING	529

STRUCTUREACTIVITY STUDIES OF SOMATOSTATIN AHALOGS SUBSTITUTED AT POSITIONS 4 AND 5	535

SYNTHESIS OF SOMATOSTATIN ANALOGUES OF REDUCED SUSCEPTIBILITY TOWARDS INTESTINAL ENZYMES	539

IMMUNOPEPTIDÉS	543

PREDICTION OF HUMAN RENIN EPITOPES USING A NEW COMPUTER ALGORITHM	549

DESIGN AND SYNTHESIS OF IMMUNOGENIC COMPLEXES BUILT UP OF A PEPTIDE ANTIGEN GLYCOPEPTIDE ADJUVANT AND POLY...	553

THYMULIN ANALOGUES FOR PROBING SPECIFIC BINDING SITES ON LYMPHOBLASTOID CELLS	557

SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF ADAMANTYLAMIDE ANALOGS OF MÜRAMYLDIPEPTIDE MDP	561

IMMUNOGENICITY OF HEPATITIS B SURFACE ANTIGEN SYNTHETIC PEPTIDE ANALOGUES	565

SYNTHESIS AND ANTIGENIC PROPERTIES OF PEPTIDES CORRESPONDING TO 200210 SEQUENCE OF p28supsis supONCOPROTEIN CO...	569

SYNTHETIC SEQUENCES OF CHOLERA TOXIN B SUBUNIT ARE IMMUNOGENIC PER OS AND DO NOT INDUCE ORAL TOLERANCE	573

SYNTHESIS OF LARGE NUMBERS OF COVALENTLY BOUND PEPTIDES IN ORDER TO DETERMINE THE SPECIFICITY OF PEPTIDE ANT...	577

SYNTHESIS AND IMMUNOLOGICAL ACTIVITY OF PEPTIDES OF THE THYMUS GLAND	581

STRUCTUREACTIVITY RELATIONSHIPS STUDIES OF DIPHTHERIA TOXIN USING SYNTHETIC PEPTIDES THAT ELICIT TOXINREACTI...	585

ENZYME SUBSTRATES AND INHIBITORS	591

POSSIBLE INVOLVEMENT OF AN ACYLHISTIDINE INTERMEDIATE	595

PREPARATION AND PROPERTIES OF SELECTIVELY εNHsub2sub ACYLATED PANCREATIC PHOSPHOLIPASES Asub2sub	601

INTRAMOLECULARLY QUENCHED FLUOROGENIC SUBSTRATES FOR AMINOPEPTIDASE P IN HUMAN SERUM	605

SENSITIVE CHYMOTRYPSIN DETERMINATION USING FLUOROGENIC SUBSTRATES CONTAINING 2QUINOLINONE DERIVATIVES	611

OTHER BIOLOGICALLY ACTIVE PEPTIDES	615

EVALUATION OF RECEPTOR SITES FOR PLASMODIUM FALCIPARUM MALARIA ON HUMAN ERYTHROCYTES CHEMICAL SYNTHESIS...	619

STRUCTURAL REQUIREMENTS FOR DESENSITIZATION OF SMOOTH MUSCLE TO ANGIOTENSIN II	623

STRUCTURE ACTIVITY RELATIONSHIP ON NEW PEPTIDE INHIBITORS ON THE ANGIOTENSIN CONVERTING ENZYME	627

FURTHER SYNTHETIC STUDIES ON POSITION 1 OF ANGIOTENSIN II	633

CONFIRMATION OF DIMERIC STRUCTURE OF HUMAN BETAATRIAL NATRIURETIC POLYPEPTIDE ßhANP BY SYNTHESIS	637

SMALL PEPTIDES MAY BE TISSUE SPECIFIC MITOSIS INHIBITORS INDUCING TERMINAL DIFFERENTIATION	641

SYNTHESIS AND BIOLOGICAL PROPERTIES OF ANTIPARALLEL AND PARALLEL DIMERS OF αHUMAN ATRIAL NATRIURETIC PEPTIDE	647

STRUCTUREACTIVITY RELATIONSHIP OF LEPIDOPTERAN SELFDEFENCE PEPTIDE PRODUCED BY SILKWORM	651

BRADYKININ ANTAGONISTS CONTAINING HYDROXYPROLINE	655

INCLUDING STRUCTURAL INVESTIGATION	659

AMINO ACIDS ON THE BASIS OF CYCLIC βDIKETONES SYNTHESIS AND PHOTOPHYSICAL CHARACTERISTICS	663

Participants	667

Authors Index	677

Subject Index	681

זכויות יוצרים

מהדורות אחרות - הצג הכל

Peptides 1986: Proceedings of the 19th European Peptide Symposium Porto ...
<span dir=ltr>Dimitrios Theodoropoulos</span>‏
אין תצוגה מקדימה זמינה - 1987

מונחים וביטויים נפוצים

a-hANP acyl agonist amide amino acid amino acid analysis analogs anhydride antagonists antibodies aqueous arginine aromatic assay binding Biochem Biochemistry biological activity bond C-terminal carboxyl cells Chem chemical shifts Chemistry chromatography chymotrypsin cleavage compounds conformation coupling cyclic deprotection derivatives dermorphin dimer dipeptide domain effect enkephalin enzyme ester Fmoc formation fragment gastrin glucagon glycophorin helix hormone HPLC Hruby hydrolysis hydrophobic IGF-I inhibition Institute insulin interaction Introduction membrane methanol method molecular molecule obtained OBzl opioid oxazolone peptide synthesis polymer polypeptide position potency prepared presence Proc Prof protecting groups protein Protein Res proton purified reaction reagents receptor residues resin Results and Discussion selectivity sequence side chain solid phase solution solvent somatostatin specific spectra structure studies substrates Table vasopressin yield

מידע ביבליוגרפי

כותרת	Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986
עורך	Dimitrios Theodoropoulos
מהדורה	הדפסה חוזרת
הוצאה	Walter de Gruyter GmbH & Co KG, 2019
ISBN	311086424X, 9783110864243
אורך	703 עמודים

ייצא ציטוט ביביליוגרפי	BiBTeX EndNote RefMan

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