The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving TreatmentThe Experiment, 8 באפר׳ 2014 - 344 עמודים Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. |
תוכן
The Chromosome and the Disease 19591990 | 13 |
The First Clue | 15 |
Three Hundred Words | 19 |
Investigating a Chicken Virus | 25 |
Right Number Wrong Place | 33 |
The Surprising Source of the Chicken Cancer Gene | 40 |
Consummate Instigators | 49 |
Where the Kinase Hangs the Keys | 53 |
Becoming a Doctor and Then a Scientist | 95 |
Turning a Protein into a Drug Target | 104 |
A Machine with a Virus for a Motor | 112 |
Plucking the LowHanging Fruit | 116 |
A Drug in Search of a Disease | 120 |
Two Endings | 129 |
Human Trials 19982001 | 173 |
Aftermath | 241 |
A Chemical Amputation | 57 |
Stripping Away the Fur and the Fat | 64 |
A Funny New Protein | 69 |
The First Sign of a Human Cancer Gene | 75 |
Spelling Out the Translocation | 81 |
That Word Is Oncogenes | 87 |
Rational Design 19831998 | 93 |
Survival Time | 270 |
Glossary | 277 |
References | 287 |
Acknowledgments | 295 |
Photo Credits | 307 |
Reading Group Guide | 313 |
מהדורות אחרות - הצג הכל
The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the ... <span dir=ltr>Jessica Wapner</span> אין תצוגה מקדימה זמינה - 2014 |